Phenotypes Associated with This Genotype

Genotype
MGI:4457056

• Allelic Composition: Bcor^{Gt(DB0053)Wtsi}/Y
• Genetic Background: chimera involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Bcor^{Gt(DB0053)Wtsi}/Y chimeras at E8.5 exhibit ventral forebrain fusion and microcephaly

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:160967 )

♂ • by E9.5

nervous system

abnormal forebrain development ( J:160967 )

♂ • apparent fusion of the ventral forebrain

cardiovascular system

failure of heart looping ( J:160967 )

♂ • heart formation is stalled at the symmetrical loop stage

embryo

incomplete somite formation ( J:160967 )

♂ • somite formation is arrested after the formation of the first 5-6 somites

growth/size/body

microcephaly ( J:160967 )

♂ • small under developed head