Phenotypes Associated with This Genotype

Genotype
MGI:4457013

• Allelic Composition: Porcn^{Gt(CSD256)Byg}/Y
• Genetic Background: chimera involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Porcn^{Gt(CSD256)Byg}/Y chimera at E7.5 exhibits abnormal embryonic tissue morphology

mortality/aging

prenatal lethality ( J:186934 )

• only a single liveborn male chimera is found

embryo

abnormal embryonic tissue morphology ( J:160967 )

♂ • defective tissues in embryos fully derived from mutant ES cells

integument

dermal cyst ( J:186934 )

• dermoid cyst in one of the ventral skin lesions

alopecia ( J:186934 )

• lower dorsal skin defect with alopecia

thin epidermis ( J:186934 )

• in skin lesions

skin lesions ( J:186934 )

• lesions show a thin epidermis with presence of a dermoid cyst in one of the ventral lesions

reproductive system

abnormal vas deferens morphology ( J:186934 )

♂ • a cystic intra-abdominal structure is present that appears to be a dilated obstructed vas deferens

true hermaphroditism ( J:186934 )

• chimera has a single ovary with oviduct and a hypoplastic testis

infertility ( J:186934 )

limbs/digits/tail

abnormal digit morphology ( J:186934 )

• hypoplastic

fused phalanges ( J:186934 )

growth/size/body

abnormal ventral body wall morphology ( J:186934 )

• midline ventral wall defects

dermal cyst ( J:186934 )

• dermoid cyst in one of the ventral skin lesions

renal/urinary system

hydronephrosis ( J:186934 )

skeleton

fused phalanges ( J:186934 )