Phenotypes Associated with This Genotype

Genotype
MGI:4457004

• Allelic Composition: Relb^tm1Brv/Relb^tm1Brv
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

spleen hyperplasia ( J:85808 )

• 3-fold increase in total splenocytes

decreased dendritic cell number ( J:85808 )

• frequency and absolute number of CD4+ dendritic cells is reduced about 4-fold

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

immune system

spleen hyperplasia ( J:85808 )

• 3-fold increase in total splenocytes

decreased dendritic cell number ( J:85808 )

• frequency and absolute number of CD4+ dendritic cells is reduced about 4-fold

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

growth/size/body

spleen hyperplasia ( J:85808 )

• 3-fold increase in total splenocytes