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Phenotypes Associated with This Genotype
Genotype
MGI:4456175
Allelic
Composition		 Erbb2tm1Haus/Erbb2tm1Klee
Gfra1tm3Jmi/Gfra1+
Myf5tm3(cre)Sor/Myf5+
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2tm1Klee mutation (0 available); any Erbb2 mutation (59 available)
Gfra1tm3Jmi mutation (0 available); any Gfra1 mutation (31 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• the number of cholinergic motor neurons is decreased compared to in wild-type mice
decreased motor neuron number ( J:160727 )
• the number of cholinergic motor neurons is decreased compared to in wild-type mice
• mice exhibit a reduction in small Gfra1+ motor neurons compared with wild-type mice
• loss of gamma-motor neurons is intermediate to wild-type mice and Egr3tm1Jmi homozygotes
• mice exhibit a decrease in large diameter motor neurons compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory