Phenotypes for Actb Sirt1 MGI:4456088 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Actb^{tm3.1(Sirt1)Npa}/Actb⁺ Sirt1^tm1Mcby/Sirt1^tm1Mcby
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm3.1(Sirt1)Npa} mutation (1 available); any Actb mutation (55 available)
Sirt1^tm1Mcby mutation (2 available); any Sirt1 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:160212 )

N	• unlike Sirt1^tm1Mcby homozygotes, mice are fertile

growth/size/body

growth/size/body region phenotype ( J:160212 )

N	• unlike Sirt1^tm1Mcby homozygotes, mice exhibit normal body size and weight

vision/eye

vision/eye phenotype ( J:160212 )

N	• unlike Sirt1^tm1Mcby homozygotes, eyelids open

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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