About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4456087
Allelic
Composition		 Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm1Mcby mutation (2 available); any Sirt1 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
female infertility ( J:160212 , J:241633 )
(J:160212)
(J:241633)
male infertility ( J:160212 , J:241633 )
(J:160212)
(J:241633)

behavior/neurological

craniofacial
abnormal palatal rugae morphology ( J:241633 )
• rugae of the hard palate are disorganized

growth/size/body
abnormal palatal rugae morphology ( J:241633 )
• rugae of the hard palate are disorganized
short snout ( J:241633 )
decreased body size ( J:160212 , J:241633 )
decreased body weight ( J:160212 )

digestive/alimentary system
abnormal palatal rugae morphology ( J:241633 )
• rugae of the hard palate are disorganized
abnormal salivary gland morphology ( J:241633 )
• lymphoid infiltration of salivary gland in almost all mice; infiltration is more extensive than in Sirt1tm3.1 mice

vision/eye
abnormal lacrimal gland morphology ( J:241633 )
• lymphoid infiltration of lacrimal gland in almost all mice; infiltration is more extensive than in Sirt1tm3.1 mice
ocular hypotelorism ( J:241633 )
• interorbital distance is reduced

endocrine/exocrine glands
abnormal salivary gland morphology ( J:241633 )
• lymphoid infiltration of salivary gland in almost all mice; infiltration is more extensive than in Sirt1tm3.1 mice
abnormal lacrimal gland morphology ( J:241633 )
• lymphoid infiltration of lacrimal gland in almost all mice; infiltration is more extensive than in Sirt1tm3.1 mice

immune system
increased autoantibody level ( J:241633 )
• increased levels of La and Ro autoantibodies

mortality/aging
perinatal lethality ( J:241633 )
• high levels of perinatal lethality

respiratory system
hyperpnea ( J:241633 )
• elevated respiration

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory