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Phenotypes Associated with This Genotype
Genotype
MGI:4455033
Allelic
Composition
Kmt2atm2(MLLT3)Thr/Kmt2a+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm2(MLLT3)Thr mutation (1 available); any Kmt2a mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

neoplasm
• predominantly acute myeloid leukemia (AML) involving immature myeloblasts and extramedullary leukemia
• a minority of the observed leukemia is acute lymphoblastic leukemia (ALL)
• 50% of heterozygotes succumb to AML at 5 months of age
• almost all mice develop malignancy within 1 1/2 years

hematopoietic system
• abnormal hematopoietic differentiation resulting in an accumulation of Mac-1/Gr-1 double-positive mature myeloid cells in the bone marrow preceded the onset of AML, as early as 6 days of age

immune system

liver/biliary system

renal/urinary system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:56340


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/21/2021
MGI 6.17
The Jackson Laboratory