Phenotypes Associated with This Genotype

Genotype
MGI:4454437

• Allelic Composition: Tg(S100a4-TK)M31Egn/0
• Genetic Background: involves: BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased sensitivity to induced cell death ( J:160213 )

• cultured renal tubular epithelium cells do not exhibit sensitivity to gancyclovir unlike similarly treated 3T3 fibroblasts

increased sensitivity to induced cell death ( J:160213 )

• mice subjected to surgical ureteral obstruction and treated with gancyclovir exhibit fewer S100a4+ cells in obstructed kidneys compared with similarly treated wild-type mice or Tg(S100a4-Tk)M31Egn mice subjected to surgical ureteral obstruction and treated with vehicle alone

• cultured fibroblast cells exhibit increased sensitivity to gancyclovir unlike similarly treated wild-type fibroblasts

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:160213 )

• mice subjected to surgical ureteral obstruction and treated with gancyclovir exhibit fewer S100a4+ cells and decreased fibrosis in obstructed kidneys compared with similarly treated wild-type mice or Tg(S100a4-Tk)M31Egn mice subjected to surgical ureteral obstruction and treated with vehicle alone

abnormal response to injury ( J:160213 )

• mice subjected to surgical ureteral obstruction and treated with gancyclovir exhibit fewer S100a4+ cells and decreased fibrosis in obstructed kidneys compared with similarly treated wild-type mice or Tg(S100a4-Tk)M31Egn mice subjected to surgical ureteral obstruction and treated with vehicle alone

renal/urinary system

abnormal kidney morphology ( J:160213 )

• mice subjected to surgical ureteral obstruction and treated with gancyclovir exhibit fewer S100a4+ cells and decreased fibrosis in obstructed kidneys compared with similarly treated wild-type mice or Tg(S100a4-Tk)M31Egn mice subjected to surgical ureteral obstruction and treated with vehicle alone