Phenotypes Associated with This Genotype

Genotype
MGI:4454326

• Allelic Composition: Cd226^tm1.1Cln/Cd226^tm1.1Cln
• Genetic Background: B6.129P2-Cd226^tm1.1Cln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased T cell proliferation ( J:159749 )

• decrease in the percentage of dividing CD8 T cells in response to stimulation by staphylococcal enterotoxin B pulsed A20 B cells or A20 B cells transfected with murine Pvr

hematopoietic system

decreased T cell proliferation ( J:159749 )

• decrease in the percentage of dividing CD8 T cells in response to stimulation by staphylococcal enterotoxin B pulsed A20 B cells or A20 B cells transfected with murine Pvr

impaired natural killer cell mediated cytotoxicity ( J:159749 )

• NK cells do not appreciably kill B16F10 tumor cells

• however, the ability to kill YAC-1 cells is unimpaired

immune system

decreased T cell proliferation ( J:159749 )

• decrease in the percentage of dividing CD8 T cells in response to stimulation by staphylococcal enterotoxin B pulsed A20 B cells or A20 B cells transfected with murine Pvr

impaired natural killer cell mediated cytotoxicity ( J:159749 )

• NK cells do not appreciably kill B16F10 tumor cells

• however, the ability to kill YAC-1 cells is unimpaired

decreased inflammatory response ( J:209990 )

• significantly increased survival rates after LPS-induced endotoxicosis at 0.5 or 0.75 mg LPS/30 g levels

neoplasm

increased metastatic potential ( J:159749 )

• with lower tumor doses mice have significantly higher numbers of B16F10 lung metastases than do wild-type

• the injection of the mouse prostate carcinoma, RM-1, at all tumor doses inoculated, results in significantly higher numbers of RM-1 lung metastases than in wild-type

increased tumor growth/size ( J:159749 )

• accelerated tumor growth is observed after subcutaneous injection of B16F10 compared to wild-type

• unlike wild-type mice, mice fail to reject the subcutaneous injection of a colon carcinoma cell line, MC38,that has been transfected with OVA

abnormal tumor susceptibility ( J:209990 )

• more lung metastases after injection of B16F10 melanoma cells into tail vein