Phenotypes for Gli3 Hand2 Tg(Prrx1-cre)1Cjt MGI:4453963 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Hand2^tm1.1Zllr/Hand2^tm1.2Zllr Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129 * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Hand2^tm1.1Zllr mutation (0 available); any Hand2 mutation (12 available)
Hand2^tm1.2Zllr mutation (0 available); any Hand2 mutation (12 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:159210 )

• digits with undetermined identities in forelimb autopod at E14.5

postaxial polydactyly ( J:159210 )

• extreme postaxial polydactyly in forelimb autopod at E14.5

preaxial polydactyly ( J:159210 )

• extreme preaxial polydactyly in forelimb autopod at E14.5

abnormal forelimb stylopod morphology ( J:159210 )

• shortening of the stylopod in forelimbs at E14.5

abnormal forelimb zeugopod morphology ( J:159210 )

• symmetrical forelimb zeugopodal bones and elbow joints at E14.5

abnormal limb development ( J:159210 )

• duplicated elbow-like structure in forelimbs at E14.5

• stunted forelimbs at E14.5

• little phenotypic variability

• survival of the zeugopod and autopod progenitors is restored in contrast to Tg(Prrx1-cre)1Cjt/o, Hand2^tm1.1Zllr, Hand2^tm1.2Zllr limbs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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