limbs/digits/tail
• distal truncations of the forelimb skeleton and loss of the autopod in most severely affected cases at E14.5 (35%)
• fused tarsal bones in hindlimb at E14.5
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• variable skeletal phenotypes at E14.5
• shortened and fused radius and ulna in most severely affected cases (35%)
• formation of two misplaced zeugopodal bones (39%) in the most hypomorphic phenotype (weak)
• formation of one zeugopodal bone (26%) in the less hypomorphic phenotype (intermediate)
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• formation of an autopod with 4-5 digits in hindlimb at E14.5
• the formation of digit 2 and/or 3 in hindlimb is always affected
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• variable skeletal phenotypes in forelimb at E14.5
• distal truncations of the forelimb skeleton and loss of the autopod in most severely affected cases at E14.5 (35%)
• formation of three anterior digits and a hypoplastic digit that resembles digit 4 (39%) in the most hypomorphic phenotype (weak) in forelimb
• formation of two digits (26%) in the less hypomorphic phenotype (intermediate) in forelimb
• formation of an autopod with 4-5 digits in hindlimb at E14.5
• the formation of digit 2 and/or 3 in hindlimb is always affected
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• in the most severely affected forelimb buds, the apoptotic domain expands distal-anterior along the entire proximo-distal axis at E10.25, E10.75 and E11
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cellular
• in the most severely affected forelimb buds, the apoptotic domain expands distal-anterior along the entire proximo-distal axis at E10.25, E10.75 and E11
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• in the most severely affected forelimb buds, the apoptotic domain expands distal-anterior along the entire proximo-distal axis at E10.25, E10.75 and E11
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