Phenotypes Associated with This Genotype

Genotype
MGI:4453324

• Allelic Composition: Ltbr^tm1Avt/Ltbr^tm1Avt; Tg(Rorc-cre)1Litt/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )

• died at day 8-12 post-infection with C. rodentium

growth/size/body

weight loss ( J:158663 )

• exhibit weight loss post infection with C. rodentium

immune system

decreased neutrophil cell number ( J:158663 )

• reduced number of neutrophils in the colon lamina propria

abnormal chemokine level ( J:158663 )

• lower expression of CXCL1 and CXCL2 chemokines in the colon lamina propria

increased susceptibility to bacterial infection ( J:158663 )

• display weight loss, increased bacterial titers in the feces and blood and severe colon pathology after infection with Citrobacter rodentium

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )

• died at day 8-12 post-infection with C. rodentium

digestive/alimentary system

abnormal colon morphology ( J:158663 )

• display severe colon pathology post infection with C. rodentium

hematopoietic system

decreased neutrophil cell number ( J:158663 )

• reduced number of neutrophils in the colon lamina propria

homeostasis/metabolism

abnormal chemokine level ( J:158663 )

• lower expression of CXCL1 and CXCL2 chemokines in the colon lamina propria