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Phenotypes Associated with This Genotype
Genotype
MGI:4453164
Allelic
Composition		 Ptch1tm1Cklr/Ptch1+
Trp53tm1Brn/?
Pax7tm1(cre)Mrc/Pax7+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm1(cre)Mrc mutation (2 available); any Pax7 mutation (40 available)
Ptch1tm1Cklr mutation (0 available); any Ptch1 mutation (115 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased medulloblastoma incidence ( J:159972 )
• earlier tumor onset, from 32 to 65 days of age
• bortezomib treated mice have better survival

nervous system
increased medulloblastoma incidence ( J:159972 )
• earlier tumor onset, from 32 to 65 days of age
• bortezomib treated mice have better survival

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory