Phenotypes Associated with This Genotype

Genotype
MGI:4453163

• Allelic Composition: Ptch1^tm1Cklr/Ptch1⁺; Pax7^tm1(cre)Mrc/Pax7⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:159972 )

• 9 of 30 double heterozygous mice become ataxic starting around 88-100 days of age

neoplasm

increased medulloblastoma incidence ( J:159972 )

• all ataxic mice have rapidly growing tumors in the cerebellum

• high nuclear to cytoplasm ratio in tumor cells

• tumors invade the subarachnoid space

• evidence of leptomeningeal metastasis

nervous system

increased medulloblastoma incidence ( J:159972 )

• all ataxic mice have rapidly growing tumors in the cerebellum

• high nuclear to cytoplasm ratio in tumor cells

• tumors invade the subarachnoid space

• evidence of leptomeningeal metastasis