Phenotypes Associated with This Genotype

Genotype
MGI:4452600

• Allelic Composition: Cd36^tm1Frm/Cd36^tm1Frm
• Genetic Background: B6.129S4-Cd36^tm1Frm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:100140 )

• intravenous infection with encapsulated S. aureus, Reynolds strain, results in 20% death by 6-8 days compared to 0% death in similarly infected wild-type mice

• 50% of mice infected intravenously with unencapsulated S. aureus, strain 3825-4, succumb to infection compared to 0% death in similarly infected wild-type mice

immune system

impaired macrophage phagocytosis ( J:100140 )

• show a 40-50% reduction in phagocytosis of S.aureus

• comparable levels of internalization of E. coli relative to wild-type

• 60% reduction in the ability to internalize lipoteichoic acid

decreased interleukin-12 secretion ( J:100140 )

• macrophages treated with S. aureus for 4 hours show a 65-75% decrease in IL-12 secretion as compared with wild-type macrophage

• macrophages treated with lipoteichoic acid demonstrate a 60-70% decrease in IL-12 secretion

decreased interleukin-6 secretion ( J:100140 )

• macrophages treated with E.coli show a 25% decrease in the secretion of IL-6

decreased tumor necrosis factor secretion ( J:100140 )

• macrophages treated with S. aureus for 4 hours show a 65-75% decrease in TNF alpha secretion as compared with wild-type macrophage

• macrophages treated with lipoteichoic acid demonstrate a 60-70% defect in TNF secretion

• macrophages treated with E.coli show a 25% decrease in the secretion of TNF alpha

abnormal response to infection ( J:100140 )

• pericardial and perinephric abscess formation in mice infected intravenously with unencapsulated S. aureus

• perinephric abscess formation in 50% of mice infected intravenously with encapsulated S.aureus

increased susceptibility to bacterial infection induced morbidity/mortality ( J:100140 )

• intravenous infection with encapsulated S. aureus, Reynolds strain, results in 20% death by 6-8 days compared to 0% death in similarly infected wild-type mice

• 50% of mice infected intravenously with unencapsulated S. aureus, strain 3825-4, succumb to infection compared to 0% death in similarly infected wild-type mice

sepsis ( J:100140 )

• mice infected with encapsulated S. aureus, Reynolds strain, develop bacteraemia, resulting in a 3.8 x 10^9 S. aureus colony forming units per milliliter of blood on day

cardiovascular system

abnormal pericardium morphology ( J:100140 )

• 100% of the surviving mice infected intravenously with unencapsulated S. aureus strain 3825-4, develop perinephric and/or pericardial abscesses

renal/urinary system

abnormal kidney morphology ( J:100140 )

• 50% of the animals infected intravenously with encapsulated S. aureus, Reynolds strain, have perinephric abscess formation whereas only 1 of 10 wild-type mice have an apparent abscess of the kidney

• 100% of the surviving mice infected intravenously with unencapsulated S. aureus strain 3825-4, develop perinephric and/or pericardial abscesses

hematopoietic system

impaired macrophage phagocytosis ( J:100140 )

• show a 40-50% reduction in phagocytosis of S.aureus

• comparable levels of internalization of E. coli relative to wild-type

• 60% reduction in the ability to internalize lipoteichoic acid

cellular

impaired macrophage phagocytosis ( J:100140 )

• show a 40-50% reduction in phagocytosis of S.aureus

• comparable levels of internalization of E. coli relative to wild-type

• 60% reduction in the ability to internalize lipoteichoic acid