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Phenotypes Associated with This Genotype
Genotype
MGI:4452490
Allelic
Composition
Tg(Prnp-ITM2B*)6Jckr/0
Tg(Thy1-APP)3Somm/0
Genetic
Background
B6.Cg-Tg(Prnp-ITM2B*)6Jckr Tg(Thy1-APP)3Somm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B*)6Jckr mutation (0 available)
Tg(Thy1-APP)3Somm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice

homeostasis/metabolism
• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory