Phenotypes Associated with This Genotype

Genotype
MGI:4452404

• Allelic Composition: \Sbds^tm1Dats/\Sbds^tm1Dats; \Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired hematopoiesis ( J:158901 )

• mice exhibit intrameduallry apoptosis of hematopoeitic progenitor cells unlike in wild-type mice

abnormal megakaryocyte morphology ( J:158901 )

• micro-megakaryocytes

decreased leukocyte cell number ( J:158901 )

decreased lymphocyte cell number ( J:158901 )

• but not neutropenia

decreased B cell number ( J:158901 )

• B cell and B cell progenitors are decreased in the bone marrow compared to in wild-type mice

abnormal myeloid leukocyte morphology ( J:158901 )

• myeloid cell frequency is increased in the bone marrow compared to in wild-type mice

abnormal neutrophil morphology ( J:158901 )

skeleton

abnormal bone structure ( J:158901 )

• texture of mineralized is altered compared to in wild-type mice

abnormal bone marrow morphology ( J:158901 )

• bone marrow vascularity is increased compared to in wild-type mice

cardiovascular system

abnormal cardiovascular system morphology ( J:158901 )

• bone marrow vascularity is increased compared to in wild-type mice

immune system

decreased leukocyte cell number ( J:158901 )

decreased lymphocyte cell number ( J:158901 )

• but not neutropenia

decreased B cell number ( J:158901 )

• B cell and B cell progenitors are decreased in the bone marrow compared to in wild-type mice

abnormal myeloid leukocyte morphology ( J:158901 )

• myeloid cell frequency is increased in the bone marrow compared to in wild-type mice

abnormal neutrophil morphology ( J:158901 )