Phenotypes Associated with This Genotype

Genotype
MGI:4452039

• Allelic Composition: \Col4a3^tm1Dec/\Col4a3^tm1Dec; \Sostdc1^tm1Myan/\Sostdc1^tm1Myan
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sostdc1^tm1Myan/Sostdc1^tm1Myan Col4a3^tm1Dec/Col4a3^tm1Dec mice show less glomerular and tubular injury than Col4a3^tm1Dec/Col4a3^tm1Dec mice

mortality/aging

extended life span ( J:158731 )

• improved survival relative to Col4a3^tm1Dec single homozygotes beyond 13 weeks of age

renal/urinary system

albuminuria ( J:158731 )

• at 6 weeks of age have less severe albuminuria than in Col4a3^tm1Dec single homozygotes

glomerulonephritis ( J:158731 )

• severity is less than in Col4a3^tm1Dec single homozygotes

glomerulosclerosis ( J:158731 )

• at 10 weeks of age mice demonstrate glomerulosclerosis associated with inflammatory cell infiltration, interstitial fibrosis, tubular atrophy, and cast formation severity is less than in Col4a3^tm1Dec single homozygotes

renal interstitial fibrosis ( J:158731 )

• at 10 weeks of age mice demonstrate interstitial fibrosis that is less severe than in Col4a3^tm1Dec single homozygotes

renal tubule atrophy ( J:158731 )

• at 10 weeks of age mice demonstrate tubular atrophy that is less than in Col4a3^tm1Dec single homozygotes

renal cast ( J:158731 )

• at 10 weeks of age mice demonstrate cast formation that is less severe than in Col4a3^tm1Dec single homozygotes

immune system

glomerulonephritis ( J:158731 )

• severity is less than in Col4a3^tm1Dec single homozygotes

homeostasis/metabolism

increased circulating creatinine level ( J:158731 )

• at 10 weeks of age creatinine level is lower than in Col4a3^tm1Dec single homozygotes

increased blood urea nitrogen level ( J:158731 )

• at 10 weeks of age BUN is lower than in Col4a3^tm1Dec single homozygotes

albuminuria ( J:158731 )

• at 6 weeks of age have less severe albuminuria than in Col4a3^tm1Dec single homozygotes

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:158731 )

• compared to Col4a3^tm1Dec single homozygotes at 5 weeks of age