Phenotypes Associated with This Genotype

Genotype
MGI:4443004

• Allelic Composition: Med1^tm2Rgr/Med1^tm2Rgr
• Genetic Background: B6.129P2-Med1^tm2Rgr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased mammary gland epithelial cell proliferation ( J:159303 )

♀ • mammary gland tissues exhibit 4 times less epithelial cell proliferation than wild-type tissue

abnormal mammary gland development ( J:159303 )

♀ • between 5 and 12 weeks, virgin females exhibit impaired mammary gland ductal growth and branch morphogenesis compared with wild-type mice

♀ • estrogen-stimulated ductal growth in ovariectomized mice is impaired compared to in similarly treated wild-type mice

♀ • however, mice exhibit normal mammary gland development during pregnancy and estrogen-stimulated uterine growth in ovariectomized mice is normal

abnormal branching of the mammary ductal tree ( J:159303 )

♀ • between 5 and 12 weeks, virgin females exhibit impaired mammary gland ductal growth and branch morphogenesis compared with wild-type mice

abnormal mammary gland epithelium morphology ( J:159303 )

♀ • mammary epithelial cells exhibit altered marker expression compared with wild-type cells indicating altered determination

integument

decreased mammary gland epithelial cell proliferation ( J:159303 )

♀ • mammary gland tissues exhibit 4 times less epithelial cell proliferation than wild-type tissue

abnormal mammary gland development ( J:159303 )

♀ • between 5 and 12 weeks, virgin females exhibit impaired mammary gland ductal growth and branch morphogenesis compared with wild-type mice

♀ • estrogen-stimulated ductal growth in ovariectomized mice is impaired compared to in similarly treated wild-type mice

♀ • however, mice exhibit normal mammary gland development during pregnancy and estrogen-stimulated uterine growth in ovariectomized mice is normal

abnormal branching of the mammary ductal tree ( J:159303 )

♀ • between 5 and 12 weeks, virgin females exhibit impaired mammary gland ductal growth and branch morphogenesis compared with wild-type mice

abnormal mammary gland epithelium morphology ( J:159303 )

♀ • mammary epithelial cells exhibit altered marker expression compared with wild-type cells indicating altered determination

cellular

decreased mammary gland epithelial cell proliferation ( J:159303 )

♀ • mammary gland tissues exhibit 4 times less epithelial cell proliferation than wild-type tissue