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Phenotypes Associated with This Genotype
Genotype
MGI:4442800
Allelic
Composition
Trp53tm1Brd/Trp53tm1Brd
Trp73tm2Mak/Trp73tm2Mak
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Brd mutation (5 available); any Trp53 mutation (237 available)
Trp73tm2Mak mutation (3 available); any Trp73 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• the increased apoptosis in response to DNA damaging agents is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels

immune system
• the increased apoptosis in response to DNA damaging agents is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels

cellular
• the increased apoptosis in response to gamma-irradiation is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels
• the increased apoptosis in response to DNA damaging agents is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels

endocrine/exocrine glands
• the increased apoptosis in response to DNA damaging agents is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels

homeostasis/metabolism
• the increased apoptosis in response to gamma-irradiation is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory