Phenotypes Associated with This Genotype

Genotype
MGI:4442799

• Allelic Composition: Trp73^tm2Mak/Trp73^tm2Mak
• Genetic Background: either: B6.129P2-Trp73^tm2Mak or (involves: 129P2/OlaHsd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:157905 )

• the sex ratio was slightly but significantly skewed at birth with fewer females being born than males

nervous system

abnormal cerebral cortex morphology ( J:157905 )

• neuronal density is significantly reduced in the motor cortex at 10 and 26-27 months of age

• by 26-27 mo of age, motor cortex thickness is reduced significantly

decreased neuron number ( J:157905 )

• neuronal density is significantly reduced in the motor cortex at 10 and 26-27 months of age

neurodegeneration ( J:157905 )

• signs of mild neurodegeneration are seen such as an increase in the number of condensed cells at 10 months of age

hematopoietic system

increased thymocyte apoptosis ( J:157905 )

• increased apoptosis in response to DNA damaging agents (cisplatin, doxorubicin, etoposide and gamma-irradiation)

immune system

increased thymocyte apoptosis ( J:157905 )

• increased apoptosis in response to DNA damaging agents (cisplatin, doxorubicin, etoposide and gamma-irradiation)

homeostasis/metabolism

increased cellular sensitivity to gamma-irradiation induced cell death ( J:157905 )

• both MEFs and thymocytes show increased sensitivity to gamma irradiation induced apoptosis

increased physiological sensitivity to xenobiotic ( J:157905 )

• both MEFs and thymocytes show increased sensitivity to DNA damaging agents including, cisplatin, doxorubicin and etoposide

cellular

increased sensitivity to induced cell death ( J:157905 )

• both MEFs and thymocytes show increased sensitivity to DNA damaging agents including, cisplatin, doxorubicin and etoposide

• however, no difference in the apoptotic response to UV treatment, TNFalpha treatment, or IL-2 withdrawal is detected

increased cellular sensitivity to gamma-irradiation induced cell death ( J:157905 )

• both MEFs and thymocytes show increased sensitivity to gamma irradiation induced apoptosis

increased thymocyte apoptosis ( J:157905 )

• increased apoptosis in response to DNA damaging agents (cisplatin, doxorubicin, etoposide and gamma-irradiation)

endocrine/exocrine glands

increased thymocyte apoptosis ( J:157905 )

• increased apoptosis in response to DNA damaging agents (cisplatin, doxorubicin, etoposide and gamma-irradiation)