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Phenotypes Associated with This Genotype
Genotype
MGI:4442372
Allelic
Composition
Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il25tm1.1Cdon mutation (0 available); any Il25 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• DSS-treated mice exhibit reduced weight loss, colonic inflammation and colon length shortening with protection from inflammatory destruction, tissue remodeling and leukocyte infiltration compared with wild-type mice
• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma
• upon ovalbumin restimulation in mice treated with ovalbumin and alum to induce asthma
• fewer infiltrating inflammatory cells in the bronchoalveolar lavage fluid after repeated intranasal allergen challenge with the Aspergillus oryzae protease and OVA protein
• reduced CCL2 in the colon tissue of DDS-treated mice compared with wild-type mice
• decreased IL22 in colon tissue of C. rodentium-infected mice
• in the colon tissue of DDS-treated mice
• in draining lymph nodes and bronchoalveolar lavage 24 hrs after last challenge, where mice were sensitized with OVA in alum at day 0 and 14, followed by intranasal challenge with OVA at day 14, 25, 26 and 27 (J:158594)
• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma (J:229778)
• in the bronchoalveolar lavage fluid after repeated allergen challenge (J:158594)
• in draining lymph nodes and bronchoalveolar lavage 24 hrs after last challenge, where mice were sensitized with OVA in alum at day 0 and 14, followed by intranasal challenge with OVA at day 14, 25, 26 and 27 (J:158594)
• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma (J:229778)
• in the bronchoalveolar lavage fluid after repeated allergen challenge (J:158594)
• in draining lymph nodes and bronchoalveolar lavage 24 hrs after last challenge, where mice were sensitized with OVA in alum at day 0 and 14, followed by intranasal challenge with OVA at day 14, 25, 26 and 27 (J:158594)
• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma (J:229778)
• in draining lymph nodes and bronchoalveolar lavage 24 hrs after last challenge , where mice were sensitized with OVA in alum at day 0 and 14, followed by intranasal challenge with OVA at day 14, 25, 26 and 27
• in the colon tissue of DDS-treated mice
• fewer infiltrating inflammatory cells in the bronchoalveolar lavage fluid after repeated intranasal allergen challenge with the Aspergillus oryzae protease and OVA protein
• Citrobacter rodentium-infected mice exhibit reduced weight loss and fecal bacteria compared with wild-type mice

respiratory system
• fewer infiltrating inflammatory cells in the bronchoalveolar lavage fluid after repeated intranasal allergen challenge with the Aspergillus oryzae protease and OVA protein

growth/size/body
• in DSS-treated mice
• Citrobacter rodentium-infected mice exhibit reduced weight loss compared with wild-type mice

digestive/alimentary system
• reduced DSS-induced colon shortening compared with wild-type mice
• DSS-treated mice exhibit reduced weight loss, colonic inflammation and colon length shortening with protection from inflammatory destruction, tissue remodeling and leukocyte infiltration compared with wild-type mice

hematopoietic system
• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma
• upon ovalbumin restimulation in mice treated with ovalbumin and alum to induce asthma


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory