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Phenotypes Associated with This Genotype
Genotype
MGI:4442182
Allelic
Composition		 Ptprcltng/Ptprctm1Mak
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: 129/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprcltng mutation (3 available); any Ptprc mutation (212 available)
Ptprctm1Mak mutation (2 available); any Ptprc mutation (212 available)
Tg(TcraTcrb)425Cbn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:158876 )
• fewer Tg(TcraTcrb)425Cbn CD4+ T cells develop compared to in wild-type Tg(TcraTcrb)425Cbn mice

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:158876 )
• fewer Tg(TcraTcrb)425Cbn CD4+ T cells develop compared to in wild-type Tg(TcraTcrb)425Cbn mice

endocrine/exocrine glands

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory