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Phenotypes Associated with This Genotype
Genotype
MGI:4442179
Allelic
Composition
Ptprctm1Mak/Ptprctm1Mak
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprctm1Mak mutation (2 available); any Ptprc mutation (212 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in response to anti-mu
• however, LPS activated B cell proliferation is normal
• following stimulation with lection and TCR-CD3 cross-linking
• the transition from double positive to single positive is blocked unlike in wild-type mice
• the ratio of CD8+ to CD4+ T cells is skewed towards CD4+ T cells unlike in wild-type mice
• in the spleen, lymph nodes, and bone marrow with CD8+ T cells reduced to a greater extent than CD4+ T cells
• in mice exposed to lymphocytic choriomeningitis virus (LCMV)
• mice exposed to lymphocytic choriomeningitis virus (LCMV) fail to exhibit a T cell cytotoxic response unlike similarly treated wild-type mice
• however, mice challenged with vesicular stomatitis virus exhibit normal IgM and IgG production

hematopoietic system
• in response to anti-mu
• however, LPS activated B cell proliferation is normal
• following stimulation with lection and TCR-CD3 cross-linking
• the transition from double positive to single positive is blocked unlike in wild-type mice
• the ratio of CD8+ to CD4+ T cells is skewed towards CD4+ T cells unlike in wild-type mice
• in the spleen, lymph nodes, and bone marrow with CD8+ T cells reduced to a greater extent than CD4+ T cells
• in mice exposed to lymphocytic choriomeningitis virus (LCMV)

endocrine/exocrine glands

cellular
• in response to anti-mu
• however, LPS activated B cell proliferation is normal
• following stimulation with lection and TCR-CD3 cross-linking


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory