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Phenotypes Associated with This Genotype
Genotype
MGI:4442178
Allelic
Composition		 Csktm1Sor/Csk+
Ptprcltng/Ptprctm1Mak
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csktm1Sor mutation (2 available); any Csk mutation (27 available)
Ptprcltng mutation (3 available); any Ptprc mutation (188 available)
Ptprctm1Mak mutation (2 available); any Ptprc mutation (188 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:158876 )
• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprcltng/Ptprctm1Mak heterozygotes and comparable to in Ptprcltng homozygotes

hematopoietic system
abnormal T cell differentiation ( J:158876 )
• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprcltng/Ptprctm1Mak heterozygotes and comparable to in Ptprcltng homozygotes

endocrine/exocrine glands

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory