Phenotypes Associated with This Genotype

Genotype
MGI:4441584

• Allelic Composition: Hbb-b1^tm1Shs/Hbb-b1⁺
• Genetic Background: involves: C57BL/6CrSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

anemia ( J:81902 )

• mild anemia without signs of hemolysis

abnormal hemoglobin ( J:81902 )

• the oxygen dissociation of red blood cells shows low affinity for oxygen in vitro

decreased hemoglobin content ( J:81902 )

• in peripheral blood

homeostasis/metabolism

increased carbon dioxide production ( J:81902 )

• produce more carbon dioxide in room air and hypoxic conditions

increased oxygen consumption ( J:81902 )

• consume more oxygen in room air and hypoxic conditions

• consume more oxygen in skeletal muscles by oxidative phosphorylation

hyperoxia ( J:81902 )

• enhanced tissue oxygenation

acidosis ( J:81902 )

• mutants show low arterial blood pH associated with an elevated PaCO₂ both in room air and under hypoxic conditions

increased aerobic running capacity ( J:81902 )

• run more than twice as far as wild-type mice spontaneously on a running wheel

muscle

abnormal skeletal muscle fiber type ratio ( J:81902 )

• on histochemical staining for ATPase, show a higher percentage of type IIA fibers and a lower percentage of type IIB fibers in deep regions of the muscle

• however, show no fiber hypertrophy or atrophy

respiratory system

decreased pulmonary ventilation ( J:81902 )

• mutants consistently have depressed ventilation before and during hypoxia, although they show a similiar pattern of ventilatory responses to wild-type, such as the initial hypoxic response and subsequent depression

• mutants do not show lung disease causing hypoventilation

cellular

abnormal aerobic respiration ( J:81902 )

• succinate dehydrogenase activities in both type IIA and type IIB muscle fibers are greater in deep regions of the tibialis anterior compared to wild-type mice