Phenotypes for Myo1e MGI:4441448 MGI Mouse

enlarged kidney ( J:159163 )

increased kidney weight ( J:159163 )

• 1.5-fold

abnormal urine homeostasis ( J:159163 )

• unlike in wild-type mice, urine contains protein (mostly albumin), blood/hemoglobin, and leukocytes

increased urine protein level ( J:159163 )

albuminuria ( J:159163 )

• beginning at 3 weeks of age, albumin excretion is increased compared to in wild-type mice

hemoglobinuria ( J:159163 )

hematuria ( J:159163 )

leukocyturia ( J:159163 )

abnormal podocyte foot process morphology ( J:159163 )

• the average number of foot processes per unit length of basement membrane is decreased 2.6-fold compared to in wild-type mice

• however, slit diaphragms are present

podocyte foot process effacement ( J:159163 )

• as early as 3 weeks of age

increased renal glomerulus basement membrane thickness ( J:159163 )

• as early as 1 week of age, mice exhibit increased glomeruli basement membrane thickness compared with wild-type mice

• the thickness of the basement membrane is increased 2-fold and disrupted compared to in wild-type mice

• however, there is no accumulation of immunoglobins

abnormal renal glomerulus morphology ( J:159163 )

• as early as 1 week of age, mice exhibit abnormal glomerular ultrastructure compared with wild-type mice

abnormal glomerular capillary morphology ( J:159163 )

• closed capillary loops, partially obstructed by extracellular matrix, are observed

expanded mesangial matrix ( J:159163 )

• mice display excess extracellular matrix deposition in and around glomeruli unlike wild-type mice

glomerulosclerosis ( J:159163 )

• mice exhibit thickened glomeruli with closed capillary loops partially obstructed by extracellular matrix

renal interstitial fibrosis ( J:159163 )

abnormal proximal convoluted tubule morphology ( J:159163 )

• mice exhibit signs of tubular injury with loss of apical brush border unlike wild-type mice

proximal convoluted tubule brush border loss ( J:159163 )

• mice exhibit loss of apical brush border unlike wild-type mice

renal cast ( J:159163 )

• periodic acid-Schiff-positive casts in renal tubules

• periodic acid-Schiff-positive protein resorption droplets in proximal tubules

pale kidney ( J:159163 )

abnormal renal glomerular filtration rate ( J:159163 )

• within the first month of life

increased blood urea nitrogen level ( J:159163 )