Phenotypes Associated with This Genotype

Genotype
MGI:4441339

• Allelic Composition: Grid2^Lc/Grid2⁺
• Genetic Background: involves: STOCK Mitf^Mi-wh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal discrimination learning ( J:13161 )

• mice exhibit impaired visual discrimination learning in a water escape test compared with wild-type mice

abnormal spatial learning ( J:30686 )

• mice exhibit impaired spatial learning in a Z-maze filled with water compared with wild-type mice

abnormal motor coordination/balance ( J:158918 )

• in an Erasmus ladder test step time and overall walking pattern are abnormal

ataxia ( J:158918 )

impaired coordination ( J:158918 )

• decrease in latency to fall of a rotarod

nervous system

abnormal cochlear VIII nucleus morphology ( J:121314 )

• loss of cartwheel cells in the dorsal cochlear nucleus

decreased Purkinje cell number ( J:121314 )

• Purkinje cell loss