Phenotypes Associated with This Genotype

Genotype
MGI:4440897

• Allelic Composition: Bhlhe22^tm1Meg/Bhlhe22^tm1Meg
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:158273 )

• excessive licking along with scratching results in skin lesions in most animals

excessive scratching ( J:158273 )

• resulting in skin lesions in most animals

abnormal sensory capabilities/reflexes/nociception ( J:158273 )

• mice show significantly greated scratching behavior than wild-type in response to all pruritic agents

abnormal chemical nociception ( J:158273 )

• in response to intraplantar formalin injection, the initial early phase reaction is similar to controls, but the late phase response is significantly enhanced with the duration of licking behavior is 4 fold greater in mutants; intradermal injection in the cheek induces a scratching (itching sensation) response rather than a wiping response (pain sensation)

• mice show similar responses to nociceptive sensory assays (mechanical sensitivity, thermal sensitivity, inflammation-induced mechanical hypersensitivity) as wild-type animals at 4 weeks of age

nervous system

abnormal nervous system physiology ( J:158273 )

• elevated neural activity associated with the presence of skin lesions is observed in the dorsal horn of the spinal cord; c-Fos activity is upregulated

• no neuropathy or abnormal innervation of the skin is observed

integument

skin lesions ( J:158273 )

• by 4 weeks of age, one third of animals display self-inflicted skin lesions frequently observed on the perineum and haunches; at 8 weeks, almost all animals have lesions