Phenotypes Associated with This Genotype

Genotype
MGI:4440892

• Allelic Composition: Git1^tm1Bcb/Git1^tm1Bcb
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased vascular endothelial cell proliferation ( J:158935 )

• microvascular endothelial cell proliferation is decreased compared to in wild-type mice

mortality/aging

decreased survivor rate ( J:158935 )

neonatal lethality, incomplete penetrance ( J:158935 )

• many mice die shortly after birth

postnatal lethality, incomplete penetrance ( J:158935 )

• most mice die within the first 10 days after birth

respiratory system

abnormal lung vasculature morphology ( J:158935 )

• mice exhibit pruning of arteriolar branches and regions of marked capillary hypoperfusion unlike wild-type mice

• mice exhibit a reduction in the numb of small diameter vessels compared with wild-type mice

• however, pulmonary artery pressure is normal in surviving mice

lung hemorrhage ( J:158935 )

• newborn mice exhibit gross pleural hemorrhage unlike wild-type mice

• at 4 to 7 days after birth, mice exhibit hemorrhage in lung parenchyma unlike wild-type mice

• however, adult mice no longer exhibit pleural hemorrhage

abnormal lung development ( J:158935 )

• mice exhibit pruning of arteriolar branches and regions of marked capillary hypoperfusion unlike wild-type mice

• mice exhibit a reduction in the numb of small diameter vessels compared with wild-type mice

dilated respiratory conducting tube ( J:158935 )

• at 3 months, surviving mice exhibit increased air spaces compared with wild-type mice

respiratory distress ( J:158935 )

• severe at birth

nervous system

nervous system phenotype ( J:158848 )

N • mice exhibit normal brain morphology

N • mice exhibit normal blood brain barrier and cerebral blood flow

abnormal dendrite morphology ( J:158848 )

• dendritic length of CA1 hippocampal and cortex neurons is decreased compared with dendrites of wild-type neurons

decreased dendritic spine density ( J:158848 )

• spine density is decreased compared to in wild-type neurons

cardiovascular system

cardiovascular system phenotype ( J:158848 )

N • mice exhibit normal blood brain barrier and cerebral blood flow

decreased vascular endothelial cell number ( J:158935 )

• in the lungs

abnormal lung vasculature morphology ( J:158935 )

• mice exhibit pruning of arteriolar branches and regions of marked capillary hypoperfusion unlike wild-type mice

• mice exhibit a reduction in the numb of small diameter vessels compared with wild-type mice

• however, pulmonary artery pressure is normal in surviving mice

lung hemorrhage ( J:158935 )

• newborn mice exhibit gross pleural hemorrhage unlike wild-type mice

• at 4 to 7 days after birth, mice exhibit hemorrhage in lung parenchyma unlike wild-type mice

• however, adult mice no longer exhibit pleural hemorrhage

decreased vascular endothelial cell proliferation ( J:158935 )

• microvascular endothelial cell proliferation is decreased compared to in wild-type mice

behavior/neurological

abnormal operant conditioning behavior ( J:158848 )

• on day 3 of operant training mice make fewer active operant responses with fewer dips and rewards compared with similarly treated wild-type mice

homeostasis/metabolism

cyanosis ( J:158935 )

• at birth