Phenotypes for Lta MGI:4440879 MGI Mouse

abnormal class switch recombination ( J:80616 )

• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching

increased leukocyte cell number ( J:80616 )

• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity

• spleen architecture is severely disturbed

• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles

decreased spleen B cell follicle number ( J:80616 )

• absence of polarized B-cell follicles

absent spleen germinal center ( J:80616 )

• do not form germinal centers

absent spleen marginal zone ( J:80616 )

decreased spleen white pulp amount ( J:80616 )

• gradual reduction of white pulp size

decreased IgG level ( J:80616 )

• specific IgG antibodies are almost undetectable in SRBC immunized mutants

absent Peyer's patches ( J:80616 )

absent mesenteric lymph nodes ( J:80616 )

absent axillary lymph nodes ( J:80616 )

absent brachial lymph nodes ( J:80616 )

absent inguinal lymph nodes ( J:80616 )

absent popliteal lymph nodes ( J:80616 )

absent lymph nodes ( J:80616 )

increased susceptibility to bacterial infection ( J:80616 )

• increased susceptibility to Listeria monocytogenes infections, with mutants dying by day 8 while wild-type mice survive

• increased susceptibility to Salmonella enterica infection