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Phenotypes Associated with This Genotype
Genotype
MGI:4440610
Allelic
Composition		 Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Tg(Fcer2a-cre)5Mbu/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Pmt mutation (0 available); any Hdac2 mutation (39 available)
Tg(Fcer2a-cre)5Mbu mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation

hematopoietic system
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation

cellular
increased B cell apoptosis ( J:157903 )
• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
decreased B cell proliferation ( J:157903 )
• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory