Phenotypes Associated with This Genotype

Genotype
MGI:4440572

• Allelic Composition: Bid^tm1.1Ast/Bid^tm1.1Ast
• Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:158191 )

• unlike wild-type mice that die from fatal hepatitis within 3?4 hr of anti-Fas antibody treatment, all mutants survive

• homozygous mice develop and age normally and have no increased incidence of tumor development

• cell subset composition and total cellularity of thymus, spleen, and lymph nodes were normal

homeostasis/metabolism

decreased susceptibility to injury ( J:158191 )

• animals survive with little or no liver damage and normal serum levels of ALT and AST and normal liver architecture after injection with anti-Fas antibodies

cellular

cellular phenotype ( J:158191 )

N • unlike other reports, hematopoietic cell and fibroblasts from homozygous mice are normally sensitive to apoptotic stimuli including DNA damage and gamma-irradiation or treatment with etoposide