Phenotypes Associated with This Genotype

Genotype
MGI:4440539

• Allelic Composition: Ret^tm1.2Pern/Ret^tm1.2Pern
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131770 )

• animals die at birth

renal/urinary system

abnormal kidney development ( J:131770 )

• kidney development fails

nervous system

abnormal neuromuscular synapse morphology ( J:131770 )

• synapse development is abnormal; postsynaptic acetylcholine receptor (AChR) clustering is reduced and shows a lack of streaks of more intense specializations at neuromuscular synapses in the tongue compared to wild-type

• nerve terminal sprouting from intact terminals is often observed in contrast to control mice