Phenotypes Associated with This Genotype

Genotype
MGI:4440493

• Allelic Composition: Dnajc6^tm1Legr/Dnajc6^tm1Legr
• Genetic Background: B6.129-Dnajc6^tm1Legr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Accumulation of clathrin-coated vesicles and clathrin cages at Dnajc6^tm1Legr/Dnajc6^tm1Legr synapses from deep cerebellar nuclei

mortality/aging

postnatal lethality, incomplete penetrance ( J:158574 )

• although present in Mendelian ratios at birth, fewer than expected mice are alive at weaning

reproductive system

delayed female fertility ( J:158574 )

nervous system

abnormal synaptic vesicle number ( J:158574 )

• more clatherin-coated vesicles and clatherin cages are found in nerve terminals compared to in wild-type mice

• however, the total number of synaptic vesicles is normal

abnormal synaptic vesicle recycling ( J:158574 )

• the rate of vesicle endocytosis at hippocampal synapses is decreased compared to in wild-type mice

growth/size/body

decreased birth weight ( J:158574 )

decreased body weight ( J:158574 )

• at 1 week of age, mice are 40% lighter than wild-type mice