Analysis Tools
growth/size/body
nervous system
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• chronic intermittent hypoxia fails to evoke sensory long-term facilitation in the carotid body
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renal/urinary system
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N |
• anesthetized males exhibit no significant differences in baseline glomerular filtration rate (GFR), urine flow, sodium excretion, and potassium excretion relative to wild-type controls
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• proportionately greater decrease in renal blood flow after L-NAME administration than in controls
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• anesthetized males exhibit significantly higher baseline renal blood flow (RBF) relative to wild-type controls (4.3+/-0.4 versus 2.5+/-0.2 mL/min per gram, respectively)
• in response to i.v. infusion of Ang II, anesthetized males show a smaller % of reduction in RBF relative to wild-type controls (-8% versus -33%, respectively)
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• anesthetized males exhibit significantly lower baseline renal vascular resistance (RVR) relative to wild-type controls (16+/-1.3 versus 29+/-2.3 mm Hg/mL/min per gram, respectively)
(J:101981)
• in response to i.v. infusion of Ang II, anesthetized males show a smaller % of increase in RVR relative to wild-type controls (+73% versus +173%, respectively)
(J:101981)
• after L-NAME administration relative to controls
(J:138704)
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• conscious males exhibit a higher excretion rate of creatinine relative to wild-type controls (1.4+/-0.4 versus 1.0+/-0.2 mg/day per gram, respectively)
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• after L-NAME administration relative to controls
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• conscious males exhibit a higher basal level of urinary sodium excretion relative to wild-type controls (807+/-69 versus 545+/-94 umol/day per gram, respectively)
• however, the basal level of 24-hour urine flow is normal in conscious males
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• conscious males exhibit significantly higher urinary excretion of nitrate/nitrite relative to wild-type controls (23.7+/-3.0 versus 13.3+/-2.5 umol/day per gram, respectively)
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• in response to i.v. infusion of Ang II, anesthetized males show a 43% increase in GFR, unlike wild-type controls where GFR is not significantly altered
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cardiovascular system
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N |
• anesthetized males exhibit no significant differences in baseline mean arterial pressure relative to wild-type controls
• conscious males show no significant differences in mean systolic arterial pressure relative to wild-type controls
• i.v. administration of Ang II causes similar increments in mean arterial pressure in both genotypes
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• proportionately greater decrease in renal blood flow after L-NAME administration than in controls
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• anesthetized males exhibit significantly higher baseline renal blood flow (RBF) relative to wild-type controls (4.3+/-0.4 versus 2.5+/-0.2 mL/min per gram, respectively)
• in response to i.v. infusion of Ang II, anesthetized males show a smaller % of reduction in RBF relative to wild-type controls (-8% versus -33%, respectively)
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• anesthetized males exhibit significantly lower baseline renal vascular resistance (RVR) relative to wild-type controls (16+/-1.3 versus 29+/-2.3 mm Hg/mL/min per gram, respectively)
(J:101981)
• in response to i.v. infusion of Ang II, anesthetized males show a smaller % of increase in RVR relative to wild-type controls (+73% versus +173%, respectively)
(J:101981)
• after L-NAME administration relative to controls
(J:138704)
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• right ventricular systolic pressure is not increased by intermittent hypoxic stress as it is in controls
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homeostasis/metabolism
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• conscious males exhibit a higher excretion rate of creatinine relative to wild-type controls (1.4+/-0.4 versus 1.0+/-0.2 mg/day per gram, respectively)
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• conscious males exhibit a significantly higher 24-hour urinary excretion of NO metabolites, nitrate/nitrite, relative to wild-type controls, indicating an increase in NO bioavailability
• however, no significant changes in urinary excretion of 8-isoprostane (an indirect marker for oxidative stress) are observed
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• after L-NAME administration relative to controls
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• conscious males exhibit a higher basal level of urinary sodium excretion relative to wild-type controls (807+/-69 versus 545+/-94 umol/day per gram, respectively)
• however, the basal level of 24-hour urine flow is normal in conscious males
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• conscious males exhibit significantly higher urinary excretion of nitrate/nitrite relative to wild-type controls (23.7+/-3.0 versus 13.3+/-2.5 umol/day per gram, respectively)
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muscle
