Phenotypes Associated with This Genotype

Genotype
MGI:4440435

• Allelic Composition: Lmnb2^tm1Ccof/Lmnb2^tm1Ccof
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:158610 )

• mice die 15 to 60 minutes after birth

nervous system

abnormal neuronal migration ( J:158610 )

• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons

• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers

abnormal neuronal precursor proliferation ( J:158610 )

• E15.5, neuronal progenitor neurons in the cortex exhibit a modest reduction in proliferation compared to in wild-type mice

decreased brain size ( J:158610 )

• slightly between E16.5 and E19.5

abnormal forebrain morphology ( J:158610 )

• at E16.5, E18.5, and birth, forebrains exhibit defective neuronal layering compared to in wild-type mice with an accumulation of cells in the intermediate zone

abnormal cortical plate morphology ( J:158610 )

• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons

• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers

• at E18.5, fewer neurons reach the cortical plate compared to in wild-type mice

abnormal hippocampus layer morphology ( J:158610 )

• at E19.5 and P0, layers are more compact than in wild-type mice

abnormal cerebral cortex morphology ( J:158610 )

abnormal stratification in cerebral cortex ( J:158610 )

• as determined by marker expression

abnormal cerebellum morphology ( J:158610 )

absent cerebellar foliation ( J:158610 )

thin external granule cell layer ( J:158610 )

absent Purkinje cell layer ( J:158610 )

cellular

abnormal neuronal migration ( J:158610 )

• at E13.5, mice exhibit increased proliferation of neurons in superficial layers of the cortical plate compared with wild-type mice indicating defective migration of newer neurons past older neurons

• at E15.5, lower layers of the cortical plate exhibit reduced proliferating cells compared with wild-type mice indicating defective migration into more superficial layers

abnormal neuronal precursor proliferation ( J:158610 )

• E15.5, neuronal progenitor neurons in the cortex exhibit a modest reduction in proliferation compared to in wild-type mice