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Phenotypes Associated with This Genotype
Genotype
MGI:4438774
Allelic
Composition		 Sh2d1atm1Pls/Sh2d1atm1Pls
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Pls mutation (4 available); any Sh2d1a mutation (10 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:157915 )
• T cell to B cell antigen specific, dose dependent conjugate formation is maintained for 10 min but not for 30 min

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:157915 )
• T cell to B cell antigen specific, dose dependent conjugate formation is maintained for 10 min but not for 30 min

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory