Phenotypes Associated with This Genotype

Genotype
MGI:4438387

• Allelic Composition: Sall4^tm1Yam/Sall4^tm1Yam
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:158264 )

• though present at E3.5, no mice are found at E7.5

embryo

decreased inner cell mass proliferation ( J:158264 )

• proliferation is decreased compared to in wild-type mice

delayed blastocyst hatching from the zona pellucida ( J:158264 )

abnormal primitive endoderm morphology ( J:158264 )

• proliferation of primitive endoderm is reduced compared to in wild-type mice

absent egg cylinders ( J:158264 )

• 8 of 24 mice at E6.5

cellular

abnormal cell physiology ( J:158264 )

• embryo-derived ES cells exhibit reduced teratoma formation compared with wild-type cells

decreased cell proliferation ( J:158264 )

• embryo-derived ES cells exhibit decreased proliferation compared with wild-type cells

decreased inner cell mass proliferation ( J:158264 )

• proliferation is decreased compared to in wild-type mice