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Phenotypes Associated with This Genotype
Genotype
MGI:4438359
Allelic
Composition
Mcph1Gt(RRO608)Byg/Mcph1Gt(RRO608)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Gt(RRO608)Byg mutation (0 available); any Mcph1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• difference in survival detectable after 65 weeks of age
• difference in survival detectable after 65 weeks of age

cellular
• primary fibroblasts show a dramatic increase of nuclei displaying condensed prophase-like chromatin
• premature chromosome condensation and delayed decondensation in primary fibroblasts

reproductive system
N
• in contrast to the defect in mitosis, no abnormalities in male meiosis are detected and both males and females are fertile

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microcephaly DOID:10907 J:157993


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory