Mouse Genome Informatics
hm
    AmelxRgsc888/AmelxRgsc888
involves: C57BL/6JJcl * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
craniofacial
• in incisors ameloblasts appear to lose contact with their subadjacent matrix and their cytoplasm becomes atypically eosinophilic (J:157947)
• in the transition and maturation zones cells become highly disorganized with the ameloblasts losing their characteristic columnar morphology and forming a multi-cellular mass (J:157947)
• severely hypoplastic (J:157947)
• large areas of enamel are missing (J:157947)

growth/size
• in incisors ameloblasts appear to lose contact with their subadjacent matrix and their cytoplasm becomes atypically eosinophilic (J:157947)
• in the transition and maturation zones cells become highly disorganized with the ameloblasts losing their characteristic columnar morphology and forming a multi-cellular mass (J:157947)
• severely hypoplastic (J:157947)
• large areas of enamel are missing (J:157947)

Mouse Models of Human Disease
OMIM IDRef(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:157947