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Phenotypes Associated with This Genotype
Genotype
MGI:4438262
Allelic
Composition
AmelxRgsc888/AmelxRgsc888
Genetic
Background
involves: C57BL/6JJcl * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AmelxRgsc888 mutation (0 available); any Amelx mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• in incisors ameloblasts appear to lose contact with their subadjacent matrix and their cytoplasm becomes atypically eosinophilic
• in the transition and maturation zones cells become highly disorganized with the ameloblasts losing their characteristic columnar morphology and forming a multi-cellular mass
• severely hypoplastic
• large areas of enamel are missing

craniofacial
• in incisors ameloblasts appear to lose contact with their subadjacent matrix and their cytoplasm becomes atypically eosinophilic
• in the transition and maturation zones cells become highly disorganized with the ameloblasts losing their characteristic columnar morphology and forming a multi-cellular mass
• severely hypoplastic
• large areas of enamel are missing

growth/size/body
• in incisors ameloblasts appear to lose contact with their subadjacent matrix and their cytoplasm becomes atypically eosinophilic
• in the transition and maturation zones cells become highly disorganized with the ameloblasts losing their characteristic columnar morphology and forming a multi-cellular mass
• severely hypoplastic
• large areas of enamel are missing

Mouse Models of Human Disease
OMIM ID Ref(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:157947


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory