Mouse Genome Informatics
ht
    AmelxRgsc888/Amelx+
involves: C57BL/6JJcl * DBA/2J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix
• decrease in enamel mineral content
• but no defect in dentine mineral levels
• incisors display patchy regions of roughened, chalky white enamel
• patchy regions of chalky white enamel
• the upper and lower incisors are shortened
• incisors display patchy regions of roughened, chalky white enamel
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing
• shortened with irregular incisal edge

growth/size/body
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix
• decrease in enamel mineral content
• but no defect in dentine mineral levels
• incisors display patchy regions of roughened, chalky white enamel
• patchy regions of chalky white enamel
• the upper and lower incisors are shortened
• incisors display patchy regions of roughened, chalky white enamel
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing
• shortened with irregular incisal edge

Mouse Models of Human Disease
OMIM IDRef(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:157947