Mouse Genome Informatics
ht
    AmelxRgsc888/Amelx+
involves: C57BL/6JJcl * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
craniofacial
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards (J:157947)
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix (J:157947)
• decrease in enamel mineral content (J:157947)
• but no defect in dentine mineral levels (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• patchy regions of chalky white enamel (J:157947)
• the upper and lower incisors are shortened (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing (J:157947)
• shortened with irregular incisal edge (J:157947)

growth/size/body
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards (J:157947)
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix (J:157947)
• decrease in enamel mineral content (J:157947)
• but no defect in dentine mineral levels (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• patchy regions of chalky white enamel (J:157947)
• the upper and lower incisors are shortened (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing (J:157947)
• shortened with irregular incisal edge (J:157947)

Mouse Models of Human Disease
OMIM IDRef(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:157947