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Phenotypes Associated with This Genotype
Genotype
MGI:4438260
Allelic
Composition
AmelxRgsc888/Amelx+
Genetic
Background
involves: C57BL/6JJcl * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AmelxRgsc888 mutation (0 available); any Amelx mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards (J:157947)
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix (J:157947)
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards (J:157947)
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix (J:157947)
• decrease in enamel mineral content (J:157947)
• but no defect in dentine mineral levels (J:157947)
• decrease in enamel mineral content (J:157947)
• but no defect in dentine mineral levels (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• patchy regions of chalky white enamel (J:157947)
• patchy regions of chalky white enamel (J:157947)
• the upper and lower incisors are shortened (J:157947)
• the upper and lower incisors are shortened (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing (J:157947)
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing (J:157947)
(J:157947)
(J:157947)
• shortened with irregular incisal edge (J:157947)
• shortened with irregular incisal edge (J:157947)

growth/size/body
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards (J:157947)
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix (J:157947)
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards (J:157947)
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix (J:157947)
• decrease in enamel mineral content (J:157947)
• but no defect in dentine mineral levels (J:157947)
• decrease in enamel mineral content (J:157947)
• but no defect in dentine mineral levels (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• patchy regions of chalky white enamel (J:157947)
• patchy regions of chalky white enamel (J:157947)
• the upper and lower incisors are shortened (J:157947)
• the upper and lower incisors are shortened (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• incisors display patchy regions of roughened, chalky white enamel (J:157947)
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing (J:157947)
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing (J:157947)
(J:157947)
(J:157947)
• shortened with irregular incisal edge (J:157947)
• shortened with irregular incisal edge (J:157947)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amelogenesis Imperfecta, Type IE; AI1E 301200 J:157947


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory