Mouse Genome Informatics
tg
    Tg(HTT*)1Xwy/0
FVB-Tg(HTT*)1Xwy
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• mice exhibit decreased forebrain weight compared with wild-type mice
• mice exhibit a 17% reduction in striatal volume compared with wild-type mice
• mice exhibit a 17% reduction in cortical volume compared with wild-type mice
• at 2 months, mice exhibit protein aggregates that worsen with age unlike in wild-type mice
• at 12 months, mice exhibit protein aggregates in the cortex and striatum unlike in wild-type mice
• at 12 months, mice exhibit selective neuropathy unlike wild-type mice

behavior/neurological
• at 12 months, mice exhibit depressive-like behavior unlike wild-type mice
• mice spend less time in the light portion of a light/dark box than wild-type mice
• starting at 2 months and worsening with age

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:157723