About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4438241
Allelic
Composition
Tg(HTT*)1Xwy/0
Genetic
Background
FVB-Tg(HTT*)1Xwy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HTT*)1Xwy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit decreased forebrain weight compared with wild-type mice
• mice exhibit a 17% reduction in striatal volume compared with wild-type mice
• mice exhibit a 17% reduction in cortical volume compared with wild-type mice
• at 2 months, mice exhibit protein aggregates that worsen with age unlike in wild-type mice
• at 12 months, mice exhibit protein aggregates in the cortex and striatum unlike in wild-type mice
• at 12 months, mice exhibit selective neuropathy unlike wild-type mice

behavior/neurological
• at 12 months, mice exhibit depressive-like behavior unlike wild-type mice
• mice spend less time in the light portion of a light/dark box than wild-type mice
• starting at 2 months and worsening with age

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:157723


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory