Mouse Genome Informatics
tg
    Tg(ACTB-APP*V717F)1Colm/0
involves: C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• amphetamine-treated mice exhibit increased hyperactivity compared with similarly treated wild-type mice
• young, but not old, mice exhibit increased immobility during a forced swim test compared with wild-type mice
• mice exhibit reduced alternation in a Y-maze compared with wild-type mice
• mice exhibit reduced retention in a passive avoidance test compared with wild-type mice
• old, but not young, mice exhibit an increase in startle amplitude compared with wild-type mice
• in young, but not old, mice exhibit increased activity in an open field test and entries in an elevated plus maze or Y-maze compared with wild-type mice
• at 9 months, mice exhibit slight hyperactivity compared with wild-type mice
• however, mice exhibit normal activity levels at 22 months
• amphetamine-treated mice exhibit increased hyperactivity compared with similarly treated wild-type mice

nervous system

cellular
• in CA1 of the hippocampus

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:157859