Phenotypes Associated with This Genotype

Genotype
MGI:4438110

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ncf1^tm1Shl/Ncf1^tm1Shl
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal susceptibility to atherosclerosis ( J:154332 )

• development of atherosclerosis is considerably reduced 2 weeks after ligation of the left common carotid as compared to Apoe^tm1Unc

• atherosclerosis continues to be reduced 3 weeks after ligation of the left common carotid as compared to Apoe^tm1Unc but no longer significantly

abnormal descending thoracic aorta morphology ( J:123854 )

• aneurysms reduced to 17% of animals rather than 40% as seen in Apoe^tm1Unc mice

aortic aneurysm ( J:123854 )

• aneurisms reduced to 17% of animals rather than 90% as seen in Apoe^tm1Unc mice

• diameter and weight of aneurisms considerably reduced relative to Apoe^tm1Unc mice but still enlarged relative to controls

decreased systemic arterial systolic blood pressure ( J:123854 )

• angiotensin-II induced affect on blood pressure is blunted

immune system

decreased acute inflammation ( J:123854 )

• leukocyte infiltration into the adventitia of the aorta is attenuated