Phenotypes Associated with This Genotype

Genotype
MGI:4438062

• Allelic Composition: \Stat3^tm4Vpo/\Stat3^tm4Vpo; \Tg(MMTV-Erbb2)1Pv/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CD-1 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:157976 )

• mice develop palpable tumors significantly earlier than their littermate controls only carrying the transgene

• the presence of larger, more diffused and advanced neoplastic lesions in whole mount mammary gland preparations performed at 7, 12, and 17 weeks of age than their littermate controls only carrying the transgene

• normal proliferation rates in tumor lesions as assessed by PCNA staining

increased mammary adenocarcinoma incidence ( J:157976 )

• invasive carcinomas at 12 weeks

• tumor cells group in solid masses with small aggregates invading the surrounding fibroadipose tissue

• only atypical hyperplastic foci and few in situ carcinomas in the littermate controls only carrying the transgene

increased metastatic potential ( J:157976 )

• strongly enhanced Matrigel invasion potential in cell lines derived from tumors in mutant mice

• strongly enhanced metastatic potential, producing more and faster growing lung metastases both at 5 and 3 weeks when injected into nude mice

increased tumor growth/size ( J:157976 )

• produce tumors faster in nude mice, reaching a diameter of 10 mm 5 weeks after injection of the cell lines derived from tumors in mutant mice

• tumors produced by injection of the cell lines derived from tumors in transgene control mice grow much slower and never reach the 10-mm size

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:157976 )

• mice develop palpable tumors significantly earlier than their littermate controls only carrying the transgene

• the presence of larger, more diffused and advanced neoplastic lesions in whole mount mammary gland preparations performed at 7, 12, and 17 weeks of age than their littermate controls only carrying the transgene

• normal proliferation rates in tumor lesions as assessed by PCNA staining

increased mammary adenocarcinoma incidence ( J:157976 )

• invasive carcinomas at 12 weeks

• tumor cells group in solid masses with small aggregates invading the surrounding fibroadipose tissue

• only atypical hyperplastic foci and few in situ carcinomas in the littermate controls only carrying the transgene

cellular

abnormal actin cytoskeleton morphology ( J:157976 )

• absence of cortical actin and presence of actin stress fibers in cell lines derived from tumors in mutant mice

abnormal cell adhesion ( J:157976 )

• discontinuous E-cadherin, beta-catenin, and Zo-1 distribution in cell lines derived from tumors in mutant mice

decreased apoptosis ( J:157976 )

• reduced TUNEL-positive apoptotic nuclei in tumor lesions

abnormal cell migration ( J:157976 )

• increased migration (>2 fold) in cell lines derived from tumors in mutant mice

integument

increased mammary gland tumor incidence ( J:157976 )

• mice develop palpable tumors significantly earlier than their littermate controls only carrying the transgene

• the presence of larger, more diffused and advanced neoplastic lesions in whole mount mammary gland preparations performed at 7, 12, and 17 weeks of age than their littermate controls only carrying the transgene

• normal proliferation rates in tumor lesions as assessed by PCNA staining

increased mammary adenocarcinoma incidence ( J:157976 )

• invasive carcinomas at 12 weeks

• tumor cells group in solid masses with small aggregates invading the surrounding fibroadipose tissue

• only atypical hyperplastic foci and few in situ carcinomas in the littermate controls only carrying the transgene