Phenotypes Associated with This Genotype

Genotype
MGI:4438041

• Allelic Composition: Tg(MMTV-Erbb2)NK1Mul/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:76653 )

increased tumor latency ( J:76653 )

• Background Sensitivity: mice display 50% tumor incidence at 52 weeks of age compared to 25 weeks of age in mice on an FVB/N background

• mice ovariectomized at 18-20 days of age, but not those ovariectomized at 16-20 weeks of age, display a further delay in tumor onset (50% incidence at 62 weeks of age)

• breeding females accelerates tumor development (50% incidence at 32 weeks of age)

reproductive system

reproductive system phenotype ( J:76653 )

N • unlike in previous reports, mammary gland ductal structure is not different from controls prior to the onset of tumor formation

integument

increased mammary gland tumor incidence ( J:76653 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:76653 )