Phenotypes Associated with This Genotype

Genotype
MGI:4438040

• Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk; Tg(MMTV-Erbb2)NK1Mul/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:76653 )

increased tumor latency ( J:76653 )

• mice display 50% tumor incidence at 105 weeks of age compared to 52 weeks of age in transgenic mice wild-type for Esr1

• increasing progesterone levels accelerates tumor development

endocrine/exocrine glands

abnormal mammary gland development ( J:76653 )

♀ • rudimentary mammary gland that fails to develop beyond the prepubertal stage

♀ • however, duct structure is not different from homozygous null mice not carrying the transgene

increased mammary gland tumor incidence ( J:76653 )

integument

abnormal mammary gland development ( J:76653 )

♀ • rudimentary mammary gland that fails to develop beyond the prepubertal stage

♀ • however, duct structure is not different from homozygous null mice not carrying the transgene

increased mammary gland tumor incidence ( J:76653 )