Phenotypes Associated with This Genotype

Genotype
MGI:4437740

• Allelic Composition: Tg(Wnt1)1Hev/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

• tumor development or progression is not affected by pregnancies or ovariectomy

endocrine/exocrine glands

mammary gland duct hyperplasia ( J:54215 )

♀ • in virgin females

mammary gland alveolar hyperplasia ( J:54215 )

♀ • lobuloalveolar hyperplasia in virgin females

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

• tumor development or progression is not affected by pregnancies or ovariectomy

mammary gland hyperplasia ( J:54215 )

♀ • at 10 weeks of age in virgin females

♀ • at 6 months of age in virgin females, hyperplastic epithelium fills the entire inguinal fat pad

♀ • males display epithelial hyperplasia that does not extend into the inguinal fat pad

integument

mammary gland duct hyperplasia ( J:54215 )

♀ • in virgin females

mammary gland alveolar hyperplasia ( J:54215 )

♀ • lobuloalveolar hyperplasia in virgin females

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

• tumor development or progression is not affected by pregnancies or ovariectomy

mammary gland hyperplasia ( J:54215 )

♀ • at 10 weeks of age in virgin females

♀ • at 6 months of age in virgin females, hyperplastic epithelium fills the entire inguinal fat pad

♀ • males display epithelial hyperplasia that does not extend into the inguinal fat pad