Phenotypes Associated with This Genotype

Genotype
MGI:4437739

• Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk; Tg(Wnt1)1Hev/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

increased tumor latency ( J:54215 )

• compared to transgenic mice wild-type for Esr1

endocrine/exocrine glands

abnormal mammary gland development ( J:54215 )

♀ • virgin females display underdeveloped glands at 10 weeks of age with a hyperplastic rudimentary ductal network that lacks terminal end buds

mammary gland duct hyperplasia ( J:54215 )

♀ • in the interior of the gland in virgin females

mammary gland alveolar hyperplasia ( J:54215 )

♀ • in virgin females, regions of lobuloalveolar hyperplasia at the periphery of the gland

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

mammary gland hyperplasia ( J:54215 )

♀ • virgin females display underdeveloped glands at 10 weeks of age with a hyperplastic rudimentary ductal network that lacks terminal end buds

♀ • unlike in transgenic mice wild-type for Esr1, hyperplasia does not progress with age in virgin females

♀ • males display epithelial hyperplasia that does not extend into the inguinal fat pad similar to what is seen in females

integument

abnormal mammary gland development ( J:54215 )

♀ • virgin females display underdeveloped glands at 10 weeks of age with a hyperplastic rudimentary ductal network that lacks terminal end buds

mammary gland duct hyperplasia ( J:54215 )

♀ • in the interior of the gland in virgin females

mammary gland alveolar hyperplasia ( J:54215 )

♀ • in virgin females, regions of lobuloalveolar hyperplasia at the periphery of the gland

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

mammary gland hyperplasia ( J:54215 )

♀ • virgin females display underdeveloped glands at 10 weeks of age with a hyperplastic rudimentary ductal network that lacks terminal end buds

♀ • unlike in transgenic mice wild-type for Esr1, hyperplasia does not progress with age in virgin females

♀ • males display epithelial hyperplasia that does not extend into the inguinal fat pad similar to what is seen in females